Missing man was heading for North Lanarkshire
Bernard Smith (51) was last seen leaving his home in a Mercedes Sprinter van Sauchie at 9.45pm.
Clackmannanshire police say he was travelling to Cumbernauld, but all contact has dropped off with friends and family since then.
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Hide AdBernard is described as five foot nine inches tall and of slim build with short grey hair.
He was wearing dark jogging bottoms and a maroon hooded top with writing on the front plus white trainers.
Inspector Martin Rutland said: “Bernard’s family are anxious to trace him and we are working hard to ensure he is found as quickly as possible.”
Anyone who can help is asked to contact police on 101.